Multielectrode arrays (MEA) allow recording of electroencephalogram (EEG) signals from multiple sites simultaneously.  We have implemented skull surface MEA in a mouse model of Fragile X syndrome (Fmr KO mouse).  This enables unprecedented electrophysiological characterization of normal vs. Fmr KO mice.  In this presentation, we will describe the rationale and our early data implementing MEA in this animal model of a neuropsychiatric developmental brain disorder and some of our new findings.  With the help of computational neuroscience collaboration, we hope to increase the sophistication of our multisite in vivo electrophysiological analysis, for example involving cross-frequency correlations and coherence among brain areas.  This body of work has the capacity to elucidate new EEG "endophenotypes" of neuropsychiatric disease in relevant animal models.

Prof. Khaleel Razak